FIXUP Solution® is used the same way as 10% neutral buffered formalin, so the change sits in the stain protocol, not in specimen handling.
What it is. An alcohol-based fixative made of alcohol, distilled water and small amounts of potassium chloride, glyoxal and acetic acid. It contains no formaldehyde.
What stays the same. Containers, fixation steps and transport. FIXUP Solution® is compatible with 10% NBF without contamination, so mixed inventories during transition are not a problem.
What changes. The H&E protocol. Any reagent change needs a protocol reset. Our technical team will support protocol setup when FIXUP Solution® launches in the U.S.
IHC and molecular work. FIXUP Solution® supports IHC, including Ki-67, and preserves DNA at levels comparable to 70% ethanol fixation.
Scope. It is designed for biopsy specimens. Larger tissues or whole organs need additional in-lab testing before use.
Disposal. It is handled like other alcohol products, subject to state and local waste rules. Tell us your location and we will confirm the rules that apply. FIXUP Solution® is planned for U.S. launch in 2027. See the FIXUP Solution® product page.
