Xylene-Free Clearing Reagent
Xylene-Free Clearing Reagent
XUP™
A hydrocarbon-based clearing reagent for tissue processing and slide staining. XUP™ replaces xylene in most histology and cytology protocols without significant procedural changes.
Pre-launch samples from November 2026 · Official launch January 2027| Catalog No. | Size | Pack |
|---|---|---|
| FSOL1010 | 1000 mL | 4 / case |
| FSOL1038 | 1 gal | 4 / case |
| FSOL1050 | 5 L | 4 / case |
| FSOL1020 | 5 gal | Cube |
- Removes xylene from clearing and staining. No xylene at the tissue processor, the staining line, or in the waste container.
- Lower vapor pressure. 0.15 kPa or less at 20 °C, compared with roughly 0.8 kPa for xylene, so less solvent evaporates into the room air.
- Not classified for acute toxicity. Oral, dermal, and inhalation acute toxicity are not classified (SDS Section 11).
- Drop-in workflow. Uses the same clearing steps as xylene. Before you switch, our technical team confirms protocol settings for your exact processor model and matches your current staining.
| Composition | Petroleum-based hydrocarbon mixture (UVCB) |
| Appearance / odor | Liquid / characteristic |
| Flash point (closed cup) | Below 50 °C (122 °F), ASTM D93 |
| Boiling range | 175–260 °C (347–500 °F) |
| Vapor pressure | ≤ 0.15 kPa at 20 °C |
| Relative density | 0.70–0.80 at 20 °C |
| Viscosity | 1.6–3.0 cSt at 40 °C |
| Water solubility | Insoluble |
| Storage | Cool, well-ventilated area, container tightly closed, away from ignition sources |
| Shelf life | 2 years from date of manufacture. Use within 90 days of opening is recommended. |
| Signal word | Danger |
| Hazard statements | H226, H304, H315, H413 |
| NFPA (Health / Fire / Reactivity) | 1 / 2 / 0 |
| DOT / IATA / IMDG | UN1268, Petroleum distillates, n.o.s., Class 3, PG III. Limited Quantity provisions may apply. |
| Waste | Flammable liquid. Manage as ignitable hazardous waste under local, state, and federal regulations. |
| Tissue processors | In routine use by laboratories on Leica, Sakura, Dakewe, Diapath, and Epredia tissue processors. These are user-reported installations, not validations by the equipment manufacturers. |
| Protocol setup | Required before switching: contact our technical team with your exact processor model. Settings are confirmed for your instrument and workflow. |
| Staining | Compatible with H&E, special stains, and IHC. |
| Mounting media | XUP™ Mount (xylene-free mounting medium). |
This is the fact
The only way to truly eliminate xylene exposure in the laboratory is to eliminate xylene itself.
Validate XUP™ in Your Lab
Everything your team needs to evaluate XUP™ before switching.
Stain Evaluation SupportSend us 3 stained and 10 unstained slides from the same block. We match your current staining and deliver an optimized protocol.Request an evaluation →
XUP™ FAQsTissue processor compatibility, protocol changes, compatible mounting media, limitations, and recycling.Read FAQs →
Safety Data Sheet (SDS)XUP™ hazard classification, handling, storage, and transport information.Download PDF →
Practical GuideReplace xylene in tissue processing without rewriting your protocol: tested processors, changeover steps, limitations, and how to verify XUP™ on your tissue.Read the article →
Request an Evaluation Sample
Your first step to eliminating xylene from the lab.